Most regions of the brain operate within a well-controlled environment that is separated from the peripheral circulation by the neurovascular unit (NVU). The NVU is a dynamic entity responding to extra- and intracerebral inflammatory signals. We focus on (neuro)inflammatory events that generate modified lipids and/or lipoproteins and study their downstream signaling pathways in cells that communicate at the NVU. We utilize cell lines, primary cells, tissue culture, and animal models combined with biochemical/analytical techniques to address these questions. Our goal is to understand associations between lipid-mediated inflammatory signaling networks, cerebrovascular dysfunction, and the development of neurodegenerative diseases.