Our general interest is the regulation and function of Ca2+ as one of nature's most versatile messengers. Right from the beginning of our scientific activities, we became fascinated with how a simple messenger, as simple as Ca2+, can serve as such a specific and manifold messenger. Calcium research is challenging by various means:
to measure Ca2+ signaling in living cells, organelles or even smaller spaces requires continuous improvements of the techniques used
to understand the molecular principles of Ca2+ regulation, one needs to identify/characterize the proteins that are involved, and
to understand how Ca2+ finally affects signal transduction one needs to explore Ca2+-sensitive proteins that translate a Ca2+ signal to protein activity.