Intracellular lipid accumulation, neutral and acid lipid hydrolysis, and lipid catabolism are tightly regulated processes, which involve intracellular hydrolases, enzymes involved in lipid biosynthesis, and regulatory proteins. Excessive lipid storage in lipid droplets and lysosomes is central to the pathogenesis of prevalent metabolic diseases, such as obesity, diabetes, and atherosclerosis.
The research interests of our group focus on lipid and energy metabolism in cells and tissues, especially on the consequences of lipase deficiency on the regulation of lipid and energy metabolism in macrophages, adipocytes, the liver, and the small intestine. The interest of the laboratory also focuses on the consequences of lipase deficiency with regard to atherosclerosis susceptibility.
We utilize transgenic and knockout mouse models with loss or overexpression of lipases or lipid-synthesizing enzymes to investigate the impact of the respective enzymes on whole-body lipid and energy metabolism and atherogenesis. In addition, we are interested in cell and tissue autonomous functions of the respective enzymes.
Our work is currently supported by funding from